Combating MS with blood pressure pill

Experts of multiple sclerosis (MS) have found that the blood pressure pill which is taken by millions of people around the world can combat with multiple sclerosis. The blood pressure pill can ease the symptoms of MS & even reverse paralysis. Drugs currently used to treat MS, in which the immune system turns on the body, are of limited effectiveness and do not work for everyone.

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The chemical, called angiotensinconverting enzyme, also played a role in the inflammation responsible for much of the damage caused by MS. Dr Steinman, of Stanford University in the U.S., showed that samples of brain tissue from MS patients had high levels of angiotensin-converting enzyme.

Dr Steinman gave Lisinopril to mice before giving them a chemical that normally causes an MS-like illness in mice. The creatures remained healthy, suggesting the blood pressure drug was holding MS at bay. Strikingly, when he gave Lisinopril to mice after giving them the MS-causing chemical, paralysis was reversed. Tests showed that Lisinopril boosted production of immune cells called regulatory T cells.

These protect against autoimmune diseases such as MS by dampening down the rogue immune response that damages the body. He cautioned though that drugs that work in mice don’t necessarily work in humans. It remains to be seen whether Lisinopril can play a role in preventing the onset or slowing the progression of MS through larger clinical studies in humans.


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