Prevents Child’s breathing trouble with Eczema & Asthma link
Many young children are found with the irritating skin rash eczema which go on to develop asthma later on. But with new invention now doctors believe that they may be able to halt this progression which is also known as atopic march after finding a key substance that links the two conditions.
Doctors found a substance which is secreted by damaged skin that is circulated through the bodies & trigger asthmatic symptoms in allergen-exposed mice. Their studies suggest that if eczema is treated early & a way is found to stop the trigger substance from spreading. This could help in blocking asthma development in young patients.
Dr Raphael Kopan says, “Over the years, the clinical community has struggled to explain atopic march”, “So when we found that the skin of mice with an eczema-like condition produced a substance previously implicated in asthma, we decided to investigate further.”
He found that cells in damaged skin can secrete thymic stromal lymphopoietin (TSLP), a compound that is capable of aliciting a powerful immune response. The skin is so effective in secreting TSLP into the blood system. This helps the substance travel throughout the body. When it reaches the lungs, it triggers the hypersensitivity characteristic of asthma.
Dr Kopan said, “'We have shown that skin can act as a signaling organ and drive allergic inflammation in the lung by releasing TSLP.”, “We are excited because we've narrowed down the problem of atopic march to one molecule.” He further said, “Now it will be important to address how to prevent defective skin from producing TSLP, if that can be done, the link between eczema and asthma could be broken.”
Thymic stromal lymphopoietin (TSLP) is also produced in lungs of asthma patients & they could eventually find a way to interfere with TSLP production and thereby ease asthma development.
Doctors found a substance which is secreted by damaged skin that is circulated through the bodies & trigger asthmatic symptoms in allergen-exposed mice. Their studies suggest that if eczema is treated early & a way is found to stop the trigger substance from spreading. This could help in blocking asthma development in young patients.
Dr Raphael Kopan says, “Over the years, the clinical community has struggled to explain atopic march”, “So when we found that the skin of mice with an eczema-like condition produced a substance previously implicated in asthma, we decided to investigate further.”
He found that cells in damaged skin can secrete thymic stromal lymphopoietin (TSLP), a compound that is capable of aliciting a powerful immune response. The skin is so effective in secreting TSLP into the blood system. This helps the substance travel throughout the body. When it reaches the lungs, it triggers the hypersensitivity characteristic of asthma.
Dr Kopan said, “'We have shown that skin can act as a signaling organ and drive allergic inflammation in the lung by releasing TSLP.”, “We are excited because we've narrowed down the problem of atopic march to one molecule.” He further said, “Now it will be important to address how to prevent defective skin from producing TSLP, if that can be done, the link between eczema and asthma could be broken.”
Thymic stromal lymphopoietin (TSLP) is also produced in lungs of asthma patients & they could eventually find a way to interfere with TSLP production and thereby ease asthma development.
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